• This reaction is driven by the formation of extremely strong nitrogen-nitrogen triple bond. Diazo compounds are often prone to loss of nitrogen. Other examples of this are the Balz-Schiemann reaction, the Sandmeyer reaction, the Semi-Pinacol reaction and the Tiffeneau-Demjanov reaction.
  • Another method which can be used to remove carbonyl groups is the Clemmensen reduction.
  • This reaction often follows the Friedel-Crafts Acylation to achieve the same product as the less predictable Friedel-Crafts Alkylation.


    References:
  • Schlosser M.; Zellner A.; Tetrahedron Letters, 2001, Volume 42, Issue 34, 5863-5865
  • Bashore C. G.; Samardjiev, I. J.; Bordner, J.; Coe, J. W.; J. Am. Chem. Soc, 2003, Volume 125, Issue 11, 3268-3272