• The P=O bond is extremely strong, and its formation is often a driving force in reactions where it is possible. For other examples see the Mitsunobu reaction, the Vilsmeier reaction and the Wittig reaction.
• This reaction is intramolecular, giving an entropic favourability over an intermolecular reaction.
• In this reaction a driving force for proton loss is the gaining of aromaticity in one of the rings.
• This reaction involves a good example of electrophilic aromatic substitution.
• The electron donating substituent can be on either of the positions it is shown between.
• To form quinoline, the Skraup synthesis is used.


References:
• Boruch M.; Konwar D.J.; Org. Chem, 2002, Volume 67, Issue 20, 7138-7139
• Quiranre J.; Escolano C.; Merino A.; Bonjoch J.; J. Org. Chem., 1998, Volume 63, Issue 4, 968-976