There is an example of a more complicated
S
N
2
reaction in the first step, and an example of the
E2
reaction later on in the reaction scheme.
Intramolecular
reaction by cyclisation is entropically favourable.
References:
Ikemoto N.; Liu J.; Brands K.M.J.; McNamara J.M.; Reider P.J.;
Tetrahedron
, 2003, Volume 59, Issue 8, 1317-1325
Qiao Q.; So S.S.; Goodnow Jr. R.A.;
Org. Lett
., 2001; Volume 3 Issue 23, 3655-3658
