• The first stage of this reaction is simply an SN2 reaction.
  • Intramolecular reaction is favoured entropically in this reaction.
  • This reaction can also be carried out using NaOH as a reagent.



    • References:
  • Zhang X.X.; Lippard S.J.; J. Org. Chem., 2000, Volume 65, Issue 17, 5298-5305
  • Tanyeli C.; Ozcubukcu S.; Tetrahedron Asymmetry, 2003, Volume 14, Issue 9, 1167-1170